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Oregon lawmakers introduce legislation to protect legal recreational marijuana
Oregon lawmakers introduce legislation to protect legal recreational marijuana
Mar 30, 2017
New York City Marijuana Possession Arrests Spike in 2016
New York City Marijuana Possession Arrests Spike in 2016
Mar 8, 2017
Mаrijuаnа Cоmроundѕ Shоw Promise In Prоtесting Brаin Cells
Mаrijuаnа Cоmроundѕ Shоw Promise In Prоtесting Brаin Cells
Sep 25, 2016
 Panel grants preliminary Maryland medical marijuana licenses
Panel grants preliminary Maryland medical marijuana licenses
Sep 11, 2016
DOH report: Medical marijuana program should be expanded
DOH report: Medical marijuana program should be expanded
Sep 11, 2016

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  • Brain’s Cannabis Receptors Used to Treat Chronic Pain without Opioid Side Effects, Study Says


     

     

     

     

    There is new proof that the brain's cannabis receptors may be used to treat long-term pain without the medial side effects that come with opioid-based medications or medical marijuana.

    During the total annual reaching of the World for Neuroscience, neuroscientist, Andrea Hohman and fellow workers from Indiana School performed a live online broadcast to go over the findings of these study. You can see a saving of the broadcast here and read the following outlined in an associated news release:

    "The most exciting facet of this research is the to create the same therapeutic benefits as opioid-based pain relievers without aspect effects like dependency risk or increased tolerance over time," said Hohmann, a Linda and Jack Gill Seat of Neuroscience and professor in the IU Bloomington University of Arts and Sciences' Office of Psychological and Brain Sciences.



    The study found that a substance that modulates the activity of the brain's receptors for THC and endocannabinoids reduced chronic pain in mice. THC, or tetrahydrocannabinol, is the key psychoactive element in marijuana; endocannabinoids are natural pain-relieving substances released by the mind.

    These modulating materials, called positive allosteric modulators, or PAMs, work by binding to a just lately discovered site on a cannabinoid receptor in the mind called CB1, which differs from the website that binds THC. The PAMs were synthesized by Ganesh A. Thakur at Northeastern University or college, who is a collaborator on the analysis.

    The experts tested the effects of CB1 PAM on neuropathic pain specifically, a kind of chronic pain induced by nerve harm, which is predicted to have an impact on as much as 40 percent of cancer patients as a side-effect of chemotherapy. The scientists gave mice paclitaxel, a chemotherapy drug known to damage nerves and cause pain, and then treated them with CB1 PAM.

    After getting paclitaxel, mice became hypersensitive to both frosty and mechanised stimulations to the paw, indicating increased pain. After treatment with the CB1 PAM, the mice behaved like normal mice that didn't experience pain.

    The analysis also found facts that the use of CB1 PAM amplified the healing aftereffect of endocannabinoids with no negative side effects of a "marijuana high," such as impaired engine function. The PAMs were administered in blend with a compound to increase endocannabinoid levels in the brain by stopping their breakdown in the torso.

    In addition, the team discovered that the use of the CB1 PAM continued to be effective over time to prevent pain in mice, instead of THC and endocannabinoid breakdown inhibitors, both which stopped working with repeated dosing.

    "We discovered that the compound did not produce reward on its own, so it's unlikely a CB1 PAM would be abused as a recreational drug," Hohmann added. "Our studies also show that we can maintain or preserve therapeutic efficacy in ways that we haven't seen with some of the other classes of analgesics that are used in the clinic."

     

     

    2016-12-03 21:13:02